Research & Scientific Evidence

Understanding PD Biology

Parkinson's Disease involves multiple interconnected pathologies

Oxidative Stress & Neuroinflammation

Dopamine neurons generate reactive oxygen species (ROS) during neurotransmitter metabolism. In PD, antioxidant defenses are compromised, leading to mitochondrial dysfunction and neuroinflammation. PD Balance targets this via marula polyphenols, NAC, CoQ10, and salidroside.

Mitochondrial Dysfunction & Energy Failure

PD neurons show impaired ATP production. CoQ10 (electron transport support), NAD+ precursors (SIRT activation), and B1 (metabolic enzyme support) enhance mitochondrial bioenergetics.

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α-Synuclein Aggregation (Proteostasis)

Misfolded α-synuclein accumulates and spreads through neural circuits. PD Balance supports protein clearance through TUDCA (ER stress modulation), ambroxol (GCase enhancement), and NAC (proteostasis support).

Gut-Brain Axis Dysfunction

Dysbiosis and intestinal barrier breakdown contribute to systemic inflammation and may accelerate PD. Inulin (prebiotic) and marula polyphenols support healthy microbiota and barrier integrity.

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Key Ingredient Evidence Summary

References & Further Reading

Research foundation includes peer-reviewed literature on:

Oxidative stress in PD (Antioxidant mechanisms)
Mitochondrial dysfunction and energy metabolism in neurodegeneration
Proteostasis and α-synuclein clearance pathways
Gut-brain axis dysfunction in PD and constipation
GBA mutations and glucocerebrosidase enhancement
Lysosomal dysfunction in PD (TFEB/GCase mechanisms)
Emerging supplements in PD clinical trials

Synergistic Effects

PD Balance is designed with ingredient synergies in mind:

High Confidence: Marula polyphenols + PC (membrane stabilization), NAC + TUDCA (proteostasis), CoQ10 + NR (energy metabolism)
Medium Confidence: Ambroxol + TUDCA (lysosomal clearance), Salidroside + PS (dopamine signaling), Inulin + marula lipids (gut health)
Mechanisms Supported by Literature: Anti-oxidation/inflammation pathways well-established; motor improvements showing emerging evidence from user data and preclinical work

Note: This research summary is educational and not a substitute for professional medical advice. While PD Balance ingredients have scientific support, individual results vary. Always consult with your healthcare provider before starting any supplement regimen, especially if taking PD medications.