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Safety Profile and Quality Standards

PD Balance is formulated with patient safety as the highest priority. Every ingredient is rigorously tested and the entire product meets international quality and regulatory standards.

Food-First Formulation

85% organic marula-derived matrices combined with evidence-based co-actives for synergistic cellular effects in Parkinson's disease management.

Dual-Pouch

System

PD Balance 1 (empty stomach) supports energy metabolism and fat-soluble delivery. PD Balance 2 (with food) focuses on antioxidants and protein clearance.

Research

Backed

Every ingredient selected for preclinical and early clinical relevance to PD biology, targeting oxidative stress, proteostasis, and energy metabolism.

FDA

Approved

​Valid FDA registration (valid through December 31, 2026) with ISO 9001:2015 certification and GMP compliance from Israeli Ministry of Health.

Ingredient Safety Profiles

PD Balance 1 Ingredients

  • Marula Oil: GRAS (Generally Recognized as Safe), no known toxicity. Well-tolerated in preclinical and observational data.

  • Sunflower Lecithin: GRAS, extensively used in supplements. No contraindications.

  • Licorice Extract: Safe at the included dosage (1-3%). Long traditional use; monitor if on blood pressure medications.

  • Mannitol: GRAS, well-tolerated sugar alcohol. May have mild osmotic/laxative effects initially (usually transient).

  • Inulin: GRAS prebiotic fiber. May cause mild bloating initially; typically resolves within days.

  • Vitamin B1 (Thiamine): Water-soluble, excess excreted; no toxicity at supplemental doses.

PD Balance 2 Ingredients

  • Lyophilized Marula Fruit: GRAS, no known adverse effects. Excellent safety profile.

  • Hydroxytyrosol (HXT): Derived from olives; GRAS. Well-tolerated at supplemental doses.

  • Oleuropein: Olive polyphenol; GRAS. Safe at included concentrations; may improve glucose tolerance.

  • NAC: Generally safe and well-tolerated. Rare side effects: minor GI upset or sulfur-like breath odor (transient).

  • Salidroside: Adapton from Rhodiola; safe at standard doses. Well-researched in stress and energy studies.

  • Phosphatidylserine (PS): GRAS, excellent safety profile. Commonly used in cognitive supplements.

  • Ubiquinol-10 (CoQ10): GRAS, well-tolerated. May have mild stimulant-like properties in sensitive individuals.

  • Nicotinamide Riboside (NR): Well-studied in humans; safe at supplemental doses. Emerging safety data strong.

  • Ambroxol: Previously used as cough medicine in Europe; safe profile. Note: Check regional availability and regulations.

  • TUDCA: Bile-acid derivative; GRAS. Well-tolerated at therapeutic doses. Bitter taste mitigated by capsule format.

Potential Side Effects and Tolerability

Most Common: Mild 

  • Bloating or gas: Due to inulin (prebiotic fiber) during adjustment period. Usually resolves within 3-7 days. Start with half-dose if sensitive.

  • Mild osmotic effect: Mannitol may increase stool frequency initially. Stay hydrated.

  • Stomach upset: Rare. Take with food if experiencing nausea (though PD Balance 1 is designed for empty stomach).

Rare: Non Serious

  • Sulfur-like breath: Rare NAC side effect; usually transient and resolves with continued use.

  • Mild stimulation: Some users report enhanced alertness from CoQ10 or B1; take earlier in day if affecting sleep.

  • Allergic reactions: Extremely rare but possible with plant-based ingredients. Discontinue and consult healthcare provider if rash, itching, or swelling occurs.

Serious: Very Rare

  • Severe allergic reactions (anaphylaxis) — seek emergency care immediately

  • Liver enzyme elevations (monitor with liver disease)

  • Severe GI distress requiring medical attention

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If you experience any serious adverse effects, discontinue use and consult your healthcare provider immediately.

Contraindications and Drug Interactions

Avoid or Use with Caution if You:

  • Have severe liver or kidney disease: Consult your healthcare provider. Some ingredients metabolized hepatically.

  • Are pregnant or nursing: Limited data on supplement use during pregnancy. Discuss with OB/GYN.

  • Have a history of hypertension: Licorice may interact with blood pressure regulation. Monitor BP.

  • Are on anticoagulants (warfarin, apixaban): Polyphenols may have mild antiplatelet effects. Discuss with your doctor.

  • Have fructose intolerance or sucrase-isomaltase deficiency: Inulin and mannitol may not be tolerated. Consult your provider.

  • Are taking medications that reduce stomach acid: May slightly reduce absorption of some ingredients. Space dosing as advised.

Possible Mild Interactions

  • CoQ10 + Warfarin: May potentiate anticoagulant effect. Monitor INR closely.

  • Licorice + ACE inhibitors: May reduce efficacy; monitor blood pressure.

  • NAC + Clopidogrel: Possible interaction; discuss with healthcare provider.

  • Polyphenols + Iron supplements: May reduce iron absorption if taken simultaneously. Space doses by 2+ hours.

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⚠️ Always inform your healthcare provider of all supplements and medications you are taking. Your doctor can assess individual risk and benefit for your specific health situation.

Ingredient Safety Profiles
Potential Side Effects
Contraindications & Drugs usage
Testing and Quality Control

Testing and Quality Control

Each batch of PD Balance undergoes rigorous testing:

  • Identity Testing: Verification that ingredients are what they claim (HPLC, GC-MS)

  • Potency Assay: Confirmation that active compounds are at stated levels

  • Microbial Testing: Absence of pathogenic bacteria (E. coli, Salmonella, Listeria)

  • Heavy Metal Screening: Lead, cadmium, mercury, and arsenic below safe limits

  • Pesticide Residues: Verification of organic status; no synthetic pesticides detected

  • Moisture & Stability: Ensuring shelf-life and product integrity

  • Allergen Screening: Testing for common allergens (gluten, soy, nuts, shellfish)

Storage & Handeling

Storage and Handling

  • Store in cool, dry place: 15–25°C (59–77°F) ideal. Avoid direct sunlight and humidity.

  • Keep pouches unopened until use: Sealed foil protects from moisture and oxidation.

  • Once opened, consume immediately: Or transfer to airtight container.

  • Avoid moisture exposure: Do not store in bathroom or kitchen near steam.

  • Check expiration date: Do not use past expiration. Potency degrades over time.

  • Keep out of reach of children: Store securely; product intended for adults only.

Disclaimer: This safety information is for educational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting PD Balance or any new supplement, especially if you have pre-existing health conditions or are taking medications.
PD Balance is not intended to diagnose, treat, cure, or prevent any disease.

Special populations

​Special Populations​

We recommend consulting with your healthcare provider before use during pregnancy or lactation. While individual ingredients have long safety histories, pregnancy and nursing involve unique physiological demands. Your doctor can assess the risk-benefit ratio for your specific situation.

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